Obstructive sleep apnea syndrome in children with 22q11.2 deletion syndrome after operative intervention for velopharyngeal insufficiency

Introduction: Surgical treatment of velopharyngeal insufficiency (VPI) in 22q11.2 deletion syndrome is often warranted.In this patient population, VPI is characterized by poor palatal elevation and muscular hypotonia with an intact palate.We hypothesize that 22q11.2 deletion patients are at greater risk of obstructive sleep apnea (OSA) after surgic

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Role of the atypical chemoattractant receptor CRAM in regulating CCL19 induced CCR7 responses in B-cell chronic lymphocytic leukemia

Abstract Background The non-signalling chemokine receptors, including receptors DARC, D6 and CCX-CKR, have recently been shown to be involved in chemokine clearance and activity regulation.The human chemokine receptor Performance Freeride / Big Air CRAM (also known as HCR or CCRL2) is the most recently identified member of this atypical group.CRAM

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